Work

A Cocktail of Two Chelators Is Not Better than One Ligand in Excess to Halt Cu,Zn-(Amyloid-β)-Induced ROS Production in the Context of Alzheimer’s Disease

Year: 2025

Type: article

Abstract: In this study, we demonstrate that an excess of the nonselective chelator EDTA can effectively extract both copper(II) and zinc(II) from the amyloid-β (Aβ) peptide and halt Cu(Aβ)-catalyzed ROS production in the context of Alzheimer's disease. These findings raise questions about the relevance of a recently reported "cocktail" approach employing two different chelators that target Cu and Zn, respectively.

Source: Inorganic Chemistry

DOI: 10.1021/acs.inorgchem.5c03352

Authors: Marie Bagrel, Christelle Hureau, Enrico Falcone

Institutions: Centre National de la Recherche Scientifique, Laboratoire de Chimie de Coordination, Université de Toulouse

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Agence Nationale de la Recherche, Université de Strasbourg, Centre National de la Recherche Scientifique, H2020 European Research Council