Work

A molecular renaissance in Alzheimer's disease research: The rise of systems biology and spatial omics

Year: 2025

Type: editorial

Abstract: Recent advances in multi-omics and spatial proteomics are reshaping our understanding of Alzheimer's disease. Guo et al. 1 applied integrative multi-omics to stratify mild cognitive impairment into biologically distinct subtypes with divergent progression trajectories: one metabolically impaired and slow-progressing, the other immune-activated and rapidly declining. Current techniques such as STC-DESI, LCM-MS, and machine learning enhance regional proteomic resolution, supporting biomarker discovery and spatially targeted interventions. This work exemplifies a broader shift toward precision medicine and a systems-level molecular framework in neurodegenerative disease research.

Source: Journal of Alzheimer s Disease

DOI: 10.1177/13872877251387169

Authors: L Monserrat Perez-Navarro, Juan Carlos Lopez-Alvarenga

Institutions: Hospital General de México, The University of Texas Rio Grande Valley

Language: English

Topic: Alzheimer's disease research and treatments

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W4415285512

Cites: 11

Cited by: 1

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