Year: 2025
Type: article
Study designs: Systematic Review, Meta-Analysis
Abstract: Aim: Th2-related biomarkers may replace nasal provocation test(NPT)as the diagnostic tool for local allergic rhinitis (LAR) .This study seeks to assess the clinical utility of these markers and rank their diagnostic accuracy for LAR.Methods: Systematic searches were conducted across five electronic databases.Pooled outcomes, including sensitivity, specificity, positive likelihood ratio(PLR) , negative likelihood ratio(NLR) , and diagnostic odds ratio(DOR) , were calculated.Relative diagnostic outcomes between index tests were computed using the indirect comparison of modalities.Results: Twenty-one studies met the inclusion criteria.Nasal eosinophilia detected through nasal cytology had the highest sensitivity(0． 69)but had the lowest specificity(0． 56) .Nasal-specific IgE(nsIgE)had the lowest sensitivity(0． 48)but the highest specificity(1． 00) .The basophil activation test(BAT)had a sensitivity of 0． 56 and a specificity of 0． 94.Among the three index tests, nsIgE ranked the highest for PLR and DOR while BAT ranked the lowest for NLR.Conclusions: None of the existing Th2-related biomarkers can serve as a substitute for NPT in diagnosing LAR.
Authors: Chair: Shu Kikuta, Takeshi Tsuda
Institutions: Nihon University, The University of Osaka
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4415289038
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