Work

Research on post-COVID syndrome: current gaps and future perspectives

Year: 2025

Type: article

Abstract: While it is generally assumed that the outcome of an infectious disease is either recovery or death, post-acute infection syndromes have long been documented, representing a substantial healthcare burden with biological drivers remaining poorly understood. Among post-acute infection sequelae, post-COVID syndrome has proved to be an elusive condition with a complex and dynamic presentation. Over the past 3 years, multiple cohorts have been created to understand, prevent, and treat post-COVID-19 condition (PCC). Drawing upon the substantial experience gathered during the pandemic, this viewpoint undertakes a rigorous examination of the methodological challenges inherent in current PCC observational research. By analyzing "real-life" hurdles, we aim to provide clear guidance for future investigations into post-acute infection syndromes and enhance global preparedness for emerging health threats.

Source: International Journal of Infectious Diseases

DOI: 10.1016/j.ijid.2025.108129

Authors: Elisa Gentilotti, Anna Górska, Evelina Tacconelli

Institution: University of Verona

Language: English

Topic: Long-Term Effects of COVID-19

Subfield: Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,900