Work

Rh(III)-Catalyzed, N -Amino-Directed C–H Coupling with α-Cyano-α-Diazoesters for the Synthesis of 3-Aminocinnoline-4-Carboxylates

Year: 2025

Type: article

Abstract: Reactivity-propagating synthesis is proposed herein as a transformative synthetic practice, with both reactant reactivity and product inner reactivity programmed into the synthetic design and survival of product inner reactivity as the central goal. Rh(III)-catalyzed, N -amino-directed C–H coupling with α-cyano-α-diazoesters has been developed for the synthesis of 3-aminocinnoline-4-carboxylates. This synthetic methodology features the survival of the product inner reactivity of two heteroatom sites of nitrogen as well as amino and ester groups, allowing versatile entry into varied open-chain and ring topology structures.

Source: The Journal of Organic Chemistry

DOI: 10.1021/acs.joc.5c02197

Authors: Renpeng Zhou, Xuanzhen Han, Wenjie Yue, Zhixin Wang, Jin Zhu

Institution: Nanjing University

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Natural Science Foundation of China, Government of Jiangsu Province, Jiangsu Science and Technology Department

Awards: G117299061, G2814365926, G6916446599