Work

Treatment response to bulevirtide is linked to amelioration of portal hypertension in patients with chronic hepatitis D

Year: 2025

Type: article

Abstract: Background & Aims Portal hypertension (PH) drives decompensation in patients with advanced chronic liver disease. Effects of antiviral treatment with bulevirtide (BLV) and achievement of suggested treatment endpoints on PH in patients with chronic hepatitis D (CHD) are unknown. Methods BLV-treated CHD patients with PH were prospectively enrolled in this observational, multicenter study. Hepatic venous pressure gradient (HVPG) was measured before (BL) and after ≥12 months of BLV treatment (M12). HVPG-response (≥10% decline) rates were compared between virological (VR), biochemical (BR), and combined (CR) responders vs. non-responders as defined in the BLV phase 3 studies. Associated changes in biomarkers of bacterial translocation, (dys)angiogenesis/endothelial dysfunction and systemic inflammation (SI) were investigated. Results Of 34 patients receiving BL HVPG-measurement, 20 patients with paired HVPG-measurement and a BL CSPH (≥10mmHg HVPG) prevalence of 85% were included. At M12, HVPG significantly decreased in patients with CR (n=12; 15.5 [IQR 10.5-21.8] to 12 [IQR 7.3-15.8]mmHg; p<0.001), VR (n=14; 14.5 [IQR 10-21.3] to 12 [IQR 7.8-16.5]mmHg, p=0.003), and BR (n=16; 12.5 [IQR 10-20.5] to 10.5 [IQR 8-15]mmHg, p=0.002); but not in non-responders. All CSPH patients with CR (n=10/10) and most of VR (83%, n=10/12) and BR (85%, n=11/13) achieved HVPG-response, but no BLV non-responder. CSPH resolved in 3/17 (17.6%). Markers of bacterial translocation (sCD163; p=0.001), (dys)angiogenesis/endothelial dysfunction (Ang2; p=0.001) and SI (IFNγ, IL-1RA, sCD25/IL-2Rα, CCL3/MIP-1alpha, HGF; all p<0.05) decreased in responders but not in non-responders. Conclusion Significant HVPG-decreases accompanied by improvement of bacterial translocation, (dys)angiogenesis/endothelial dysfunction and SI are observed in CHD patients achieving BLV response. These findings provide evidence for the validity and clinical relevance of the currently recommended on-treatment response criteria. Clinical trial number NCT04863703 Impact and Implications Portal hypertension (PH) is the main mechanism driving clinical deterioration in patients with compensated advanced chronic liver disease (cACLD), for which patients with chronic hepatitis D (CHD) are at particularly high risk. This study demonstrates that in CHD patients with PH, achieving response to antiviral treatment with bulevirtide decreases hepatic venous pressure gradient (HVPG). Importantly, a clinical meaningful reduction in HVPG was observed only in treatment responders as defined by endpoints used in clinical trials, in particular, in all patients achieving combined response. Biomarkers of important pathophysiological mechanisms were also improved. The finding of a clinical meaningful HVPG decline in CHD patients responding to antiviral treatment strengthens the clinical significance of the suggested on-treatment response criteria, supporting a disease-modifying effect of BLV response, likely translating into decreased morbidity and mortality in CHD patients.

Source: JHEP Reports

DOI: 10.1016/j.jhepr.2025.101643