Crimean-Congo Hemorrhagic Fever Disease: Relationship Between Clinical Course and Apoptosis
Year: 2025
Type: article
Study design: Observational Study
Abstract: Objective: Crimean-Congo hemorrhagic fever (CCHF) is a zoonotic disease that causes significant morbidity and mortality. This study aimed to evaluate the levels of apoptosis biomarkers-clusterin, tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), caspase-8, cytochrome C, and apoptotic protease-activating factor 1 (Apaf-1)-in patients with mild and severe clinical presentations of CCHF, and to assess their relationship with disease severity. Materials and Methods: The study included adult patients admitted to our hospital with a confirmed diagnosis of CCHF. Patients were divided into two groups (mild and severe) based on the Severity Grading Score. Blood samples were analyzed for apoptosis markers using the enzyme-linked immunosorbent assay (ELISA) method. Apoptosis protein levels were measured separately during the acute and convalescent periods of the disease for both mild and severe cases. Results: =0.009). Conclusions: Apoptosis and apoptosis-related proteins play an important role in the pathogenesis of CCHF. In particular, clusterin and TRAIL may serve as useful indicators of disease severity. Their early detection could improve clinical management by enabling timely intervention for patients at risk of severe disease.
Authors: Mehmet Samet Demirel, Cigdem Kader, Emine Yesilyurt, Sebnem Eren-Gok, Ayse Erbay
Institution: Yozgat Bozok Üniversitesi
Language: English
Topic: Viral Infections and Vectors
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W4415323565
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