Year: 2025
Type: article
Study design: Case Report
Abstract: Primary hypothyroidism in children often manifests as short stature, and if untreated, it can result in pituitary hyperplasia due to chronic thyrotropin-releasing hormone (TRH) drive resulting from the loss of negative feedback by low circulating thyroid hormones, potentially leading to unnecessary surgery. We report the case of a nine-year-old patient with a persistent headache with a suspected diagnosis of a pituitary mass. Blood tests revealed severe hypothyroidism (extremely elevated thyroid-stimulating hormone (TSH) and suppressed free thyroxine (T4). The initial MRI led to a misdiagnosis of pituitary adenoma. Reversible pituitary hyperplasia completely regressed following levothyroxine therapy. This case highlights the relevance of considering hypothyroidism when evaluating pituitary masses. Thyroid function should always be assessed before considering pituitary surgery in children.
Source: Cureus
DOI: 10.7759/cureus.94880
Authors: Victoria Leal, Shokery Awadalla
Institution: Universidad FUCS
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415328059