Work

MHAT-driven copper-catalyzed hydrosilylation of alkenes: a new radical pathway for a less explored regioselectivity

Year: 2025

Type: article

Abstract: The synthesis of non-linear organosilicon compounds has received significant attention in recent years owing to their promising potential as fine chemicals. Among the various synthetic approaches, catalytic hydrosilylation of alkenes remains the most direct and atom-economical strategy, with increasing efforts focused on the use of catalysts based on first-row transition metals. Herein, we report an efficient and operationally simple protocol for the copper-catalyzed Markovnikov hydrosilylation of alkenes. Besides the new type of well-defined copper(I)-based catalytic precursors and the excellent yields obtained when using activated alkenes, the experimental evidence is consistent with a mechanism relying on a hydrogen atom transfer from a metal hydride (MHAT), which, to the best of our knowledge, has never been reported for this type of transformation. Moreover, there are only a few examples of this reactivity with copper. Therefore, this work provides a valuable contribution to current knowledge of copper chemistry and MHAT processes, highlighting their potential for the synthesis of organosilicon compounds.

Source: Journal of Catalysis

DOI: 10.1016/j.jcat.2025.116494

Authors: Antonio Torres-Calis, Eduardo Gabriel Guzmán-López, Miguel Reina, Marcos Flores-Alamo, Juventino J. García

Institution: Universidad Nacional Autónoma de México

Language: English

Topic: Organoboron and organosilicon chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,250

Funder: Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México