Meta-analysis of genome-wide association studies of hoarding symptoms in 27,651 individuals
Year: 2022
Type: review
Abstract: Hoarding Disorder (HD) is a mental disorder characterized by persistent difficulties discarding or parting with possessions, often resulting in cluttered living spaces, distress, and impairment. Its etiology is largely unknown, but twin studies suggest that it is moderately heritable. In this study, we pooled phenotypic and genomic data from seven international cohorts (N = 27,537 individuals) and conducted a genome wide association study (GWAS) meta-analysis of parent- or self-reported hoarding symptoms (HS). We followed up the results with gene-based and gene-set analyses, as well as leave-one-out HS polygenic risk score (PRS) analyses. To examine a possible genetic association between hoarding symptoms and other phenotypes we conducted cross-trait PRS analyses. Though we did not report any genome-wide significant SNPs, we report heritability estimates for the twin-cohorts between 26-48%, and a SNP-heritability of 11% for an unrelated sub-cohort. Cross-trait PRS analyses showed that the genetic risk for schizophrenia and autism spectrum disorder were significantly associated with hoarding symptoms. We also found suggestive evidence for an association with educational attainment. There were no significant associations with other phenotypes previously linked to HD, such as obsessive-compulsive disorder, depression, anxiety, or attention-deficit hyperactivity disorder. To conclude, we found that HS are heritable, confirming and extending previous twin studies but we had limited power to detect any genome-wide significant loci. Much larger samples will be needed to further extend these findings and reach a "gene discovery zone". To move the field forward, future research should not only include genetic analyses of quantitative hoarding traits in larger samples, but also in samples of individuals meeting strict diagnostic criteria for HD, and more ethnically diverse samples.
Source: Translational Psychiatry
Authors: Nora I. Strom, Dirk J. A. Smit, Talisa Silzer, Conrad Iyegbe, Christie L. Burton, René Pool, Mathieu Lemire, James J. Crowley, Jouke-Jan Hottenga, Volen Z. Ivanov, Henrik Larsson, Paul Lichtenstein, Patrik Magnusson, Christian Rück, Russell J. Schachar, Hei Man Wu, Sandra M. Meier, Jennifer Crosbie, Paul D. Arnold, Manuel Mattheisen, Dorret I. Boomsma, David Mataix-Cols, Danielle Cath
Institutions: Aarhus University, Region Stockholm, Karolinska Institutet, Humboldt-Universität zu Berlin, Stockholm Health Care Services, Institut für Psychiatrische Phänomik und Genomik, Ludwig-Maximilians-Universität München, Amsterdam Neuroscience, Amsterdam University Medical Centers, Hospital for Sick Children, King's College London, Icahn School of Medicine at Mount Sinai, Vrije Universiteit Amsterdam, University of North Carolina at Chapel Hill, Örebro University, Dalhousie University, University of Calgary, Hotchkiss Brain Institute, Mathison Centre for Mental Health Research and Education, Amsterdam Public Health, Amsterdam Reproduction Development, University Medical Center Groningen, University of Groningen, GGZ Drenthe
Language: English
Subfield: Clinical Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: gold
Estimated APC paid: $4,206
Funders: Foundation for the National Institutes of Health, U.S. Department of Health and Human Services, Wellcome Trust, Chronic Disease Research Foundation, National Institute for Health and Care Research, Department of Health and Social Care, King's College London, European Commission, ZonMw, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Karolinska Institutet, Vetenskapsrådet, Humboldt-Universität zu Berlin, Alberta Innovates, Versus Arthritis, National Institutes of Health, Canadian Institutes of Health Research, Medical Research Council, National Institute of Mental Health, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1028663679, G1389291084, G1447699044, G1777540776, G2748385693, G2752948112, G2891576335, OCD: Novel Comparative Genomic Approaches to Identify Disease and Treatment Mechanisms, BBMRI-NL2.0: The NL-Biobank Research Facility, G3121967442, G3194766268, G3321450376, G3404090561, G3444887196, Collaborative Study of Genetics of Dizygotic Twinning, G434337789, G4374337615, G4460629988, G4544423771, G4748417993, G529952714, Limited Competition: Continuation of the Center for Genomic Studies on Mental Disorders, G5520316217, G5598020036, Swedish twin registry, G5846174747, G591084189, G6073771368, G6467138992, G6838351527, G712881263, G7229602471, Netherlands Twin Registry Repository: researching the interplay between genome and environment, G7924559645, G796431723, G7991887228, Integration of Genomics & Transcriptomics in Normal Twins & Major Depression, G8367386159, G84497985, Genome-wide Association Study of Childhood Obsessive-Compulsive Traits in a General Population Sample, G9000126205, G9000177168, G9000192955
OpenAlex ID: W4309048145