Comparison of standard polymer formula versus short peptide formula in sepsis patients with acute gastrointestinal injury
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background To investigate the selection of enteral nutrition (EN) formulas for critically ill sepsis patients with acute gastrointestinal injury (AGI) grade I-II. Methods We conducted a retrospective cohort study on critically ill sepsis patients with AGI grades I-II. The primary outcomes were EN caloric adequacy on day 7, calories and protein gain from EN within 3–7 days, and the incidence of gastric retention and diarrhea after EN administration. We performed a subgroup analysis based on whether patients initiated EN within 48 h. Results In the early EN subgroup, caloric adequacy, calories and protein gain of EN on day 7 of the short-peptide group was higher than that of the standard-polymeric group (59.1% vs. 27.3%, p = 0.001; 624[0, 936] vs. 0[−360, 480], p = 0.001; 24[0, 38] vs. 0[−14.4, 19.2], p = 0.003, respectively), and the incidence of gastric retention (18.2% vs. 36.4%, p = 0.03) and diarrhea (9.1% vs. 25.5%, p = 0.02) were lower in the short-peptide group than in the standard-polymeric group. However, in the delayed EN subgroup, the caloric adequacy of EN on day 7 of the short-peptide group was lower than that of the standard-polymeric group (28.6% vs. 43.5%, p = 0.02), calories and protein gain from EN were lower in the short-peptide group than in the standard-polymeric group (960[480, 1,200] vs. 1,080[720, 1,440], p = 0.04; 38.4[19.2, 50.4] vs. 43.2[28.8, 57.6], p = 0.04, respectively). Conclusion In sepsis patients with AGI grades I–II, short-peptide formulas may be considered for early EN initiation (≤48 h), while standard-polymer formulas may be an option for late EN initiation (>48 h). Exploratory results need to be interpreted with caution and await verification of these findings through high-quality research.
Source: Frontiers in Nutrition
Authors: Youquan Wang, Yanhua Li, Yuhan Zhang, Dong Zhang
Institution: First Hospital of Jilin University
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4415345818