Plasma Metabolomic and Proteomic Signatures of Blood Pressure Management After Bariatric Surgery Among Adolescents
Year: 2025
Type: article
Abstract: BACKGROUND: Emerging omics approaches, including metabolomics and proteomics, can be integrated into obesity treatment for better blood pressure management. We tested whether preoperative metabolomic and proteomic profiles predict long-term elevated blood pressure (EBP) changes better than known risk factors in adolescents undergoing bariatric surgery. METHODS: We included 108 participants from the Teen-LABS (Teen-Longitudinal Assessment of Bariatric Surgery). Plasma untargeted metabolomics (via liquid chromatography with high-resolution mass spectrometry) and Olink proteomics were assessed pre surgery. An elastic net model with stability selection was used to identify features predictive of EBP reductions 5 years post surgery. Models including identified metabolites, proteins, and known risk factors (age, sex, race, clinical sites, parents' education level, body mass index, systolic blood pressure, and diastolic blood pressure at baseline) were compared with known-risk-factors-only models. For biological relevance, the consistency of association directions was examined in a multiethnic non-interventional adolescent cohort (n=79). RESULTS: <0.01). Higher levels of 4 metabolites (uric acid, taurocholic acid, nonadecanoic acid, and cystine) were consistently associated with reduced likelihood of EBP improvement or blood pressure improvement across cohorts. SERPINA11 (serine protease inhibitor, clade A, member 11), ICAM5 (intercellular adhesion molecule 5), and TINAGL1 (tubulointerstitial nephritis antigen-like 1) demonstrated consistent associations in both cohorts. CONCLUSIONS: This is the first study identifying potential preoperative biomarkers for EBP reductions in adolescents following bariatric surgery. Integrating metabolomics and proteomics with known risk factors substantially improved predictive models compared with known-risk-factors-only models. Larger and more diverse cohorts are needed to confirm these findings and whether identified features are associated with other blood pressure treatments.
Source: Hypertension
Authors: Shudi Pan, Zhenjiang Li, Juan Pablo Lewinger, Jesse A. Goodrich, Hongxu Wang, Sarah Rock, Carmen Chen, Todd M. Jenkins, Stephanie Sisley, Stephen R. Daniels, Douglas I. Walker, Max T. Aung, Erika Garcia, Rob McConnell, Sandrah P. Eckel, Michele A. La Merrill, Tanya L. Alderete, Zhuanghua Chen, Frank D. Gilliland, Thomas H. Inge, David V. Conti, Justin R. Ryder, Lida Chatzi
Institutions: University of Southern California, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Baylor College of Medicine, Children's Nutrition Research Center at Baylor College of Medicine, University of Colorado Anschutz, University of Colorado Denver, Emory University, University of California, Davis, Johns Hopkins University, Northwestern University, Lurie Children's Hospital
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: G1339695942, G1583036818, Continuation of Teen Longitudinal Assessment of Bariatric Surgery (Teen-LABS), Biostatistics Research Center, G2702965091, G31452788, Environmental Chemical Exposures and Longitudinal Changes of Glucose Metabolism, Insulin Sensitivity and B Cell Function in Youth, G346198372, Effects of DDE exposure on adipose tissue function, weight loss and metabolic improvement after bariatric surgery: A new paradigm for study of lipophilic chemicals, Persistent Organic Pollutants mixtures, Metabolomics Profiles and Blood Pressure among Patients after Bariatric Surgery, Environmental Exposures, Host Factors and Human Disease, G984942071
OpenAlex ID: W4415349285