Intermuscular adipose tissue in healthy human aging—effects of exercise training and implications to metabolic health
Year: 2025
Type: article
Abstract: Intermuscular adipose tissue (IMAT) accumulates in the lower leg musculature of healthy older adults. IMAT was negatively associated with the rate of glucose infusion during a hyperinsulinemic-euglycemic clamp and muscle oxidative capacity. Exercise training decreased IMAT to a greater extent in young compared with older adults. Together these data support the implication that IMAT accumulation is linked with metabolic derangements in older adults but the restorative potential of exercise in older adults needs further evaluation.
Source: Journal of Applied Physiology
Institution: Mayo Clinic
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funder: National Institute on Aging
OpenAlex ID: W4415353617