Efficacy and Blood Concentrations of Cetuximab in a Hemodialysis Patient with Tongue Squamous Cell Carcinoma: A Case Report
Year: 2025
Type: article
Study design: Case Report
Abstract: Introduction: Cetuximab is an effective therapy for unresectable locoregionally advanced head and neck cancer, but for patients with end-stage renal disease (ESRD), clinical trials seldom provide evidence for the efficacy and safety of cetuximab. Case Presentation: We report this case of 46-year-old male patient with stage IVa tongue squamous cell carcinoma who is on maintenance hemodialysis for diabetic nephropathy. He tolerated the therapy well and had a stable disease of the carcinoma. We determined cetuximab concentration and showed that pharmacokinetics of cetuximab in this ESRD patient was similar to healthy subjects. Conclusion: Cetuximab can be used safely and effectively in head and neck cancer patients with ESRD, and we have provided an example of pharmacokinetics of cetuximab in renal failure patient.
Source: Case Reports in Oncology
DOI: 10.1159/000548464
Authors: Ting-Ting Niu, Wei-Yang Zhang, Ling Han, Hui-Jie Shi, Ying Piao, Li-Wei Ren, Shi-Hai Wu
Language: English
Topic: Head and Neck Cancer Studies
Subfield: Otorhinolaryngology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,170
Award: G5246992274
OpenAlex ID: W4415354274