Work

Multivalent aptamer engineered and functionalized NK cells for enhanced adoptive immunotherapy in CD30-positive malignant lymphoma

Year: 2025

Type: article

Abstract: . Therefore, the proposed approach endows NK cells with tumor-specific targeting ability and enhances their adoptive therapeutic efficiency in CD30-positive lymphoma, showing substantial potential for application in the clinical treatment of malignant lymphoma.

Source: Molecular Therapy — Nucleic Acids

DOI: 10.1016/j.omtn.2025.102748

Authors: Fang Tan, Rui Wei, Jiqing Su, Cai Sheng, Qian Li, Yang Long, Xuyang Zhao, Liang Zhao, Shengpeng Huang, Lei Zhang, Lu Yang, Hedong Zhang, Shuanghui Yang, Huan Li

Institutions: Central South University, Xiangya Hospital Central South University, Changsha Central Hospital, University of South China, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Hospital, Second Xiangya Hospital of Central South University

Language: English

Topic: Immune Cell Function and Interaction

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,900

Funders: National Natural Science Foundation of China, Natural Science Foundation of Hunan Province, Science and Technology Department of Hubei Province

Awards: G2506273722, G4562645588, G4568342857, G659780016, G6835978584, G7880760779

OpenAlex ID: W4415354599

FWCI: 0.915

Cites: 58

Cited by: 3

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