Work

Discovery of Novel PI3K/BRD4 Dual Inhibitors for Esophageal Cancer: Rational Design, Optimization, and Senescence-Inducing Mechanisms

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c01920

Authors: Shouguo Peng, Yihui Yang, Wan Li, Songwen Lin, Shiji Chu, Tianning Xiong, Junpu Ge, Li Sheng, Jinhua Wang, Heng Xu

Institution: Chinese Academy of Medical Sciences & Peking Union Medical College

Language: English

Topic: Protein Degradation and Inhibitors

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funders: National Natural Science Foundation of China, Chinese Academy of Medical Sciences

Awards: G1486693610, G2174198254, G2381989466, G3584127899, G5949953664, G6091979950

OpenAlex ID: W4415355950

FWCI: 1.044

Cites: 38

Cited by: 4

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