Machine learning predictive model based on the corneal biomechanics of clinical data
Year: 2025
Type: article
Study design: Observational Study
Abstract: • Collected multidimensional preoperative and postoperative corneal parameters for refractive surgery patients. • Used Lasso regression to select key predictors of corneal ectasia risk. • Compared multiple machine learning models (GLM, SVM, GBM) for predictive performance. • Optimized Support Vector Machine (SVM) achieved highest AUC (0.88) for risk prediction. • Provides a practical tool for early identification of high-risk patients and personalized surgical planning. Objective: To develop and validate a machine learning model for predicting postoperative corneal ectasia risk after refractive surgery by integrating multidimensional preoperative and postoperative biomechanical parameters. Methods: A retrospective cohort of 200 patients who underwent LASIK or SMILE at Shenyang Xingqi Eye Hospital between January 2023 and December 2024 was analyzed. Variables including corneal morphology, biomechanics, and early postoperative changes were screened using Least Absolute Shrinkage and Selection Operator (LASSO) regression. Multiple algorithms—generalized linear model (GLM), gradient boosting machine (GBM), and support vector machine (SVM)—were compared via 10-fold cross-validation. The optimal SVM model was fine-tuned through grid search and further tested in a prospective temporal validation cohort (n = 40, January–September 2025). Model performance was evaluated by AUC, calibration, and decision-curve analysis. Results: LASSO identified PreopCCT, PreopKmax, CH, CRF, and early postoperative changes (PostopCCTChange1m, PostopKmaxChange3m) as key predictors. The SVM model achieved the best discrimination among all models (AUC = 0.88 in cross-validation). In prospective validation, the locked SVM maintained high accuracy (AUC = 0.984, 95% CI 0.944–1.000; sensitivity = 0.88; specificity = 0.90) with good calibration (slope = 0.96; Brier = 0.098) and net clinical benefit across threshold probabilities of 0.1–0.7. Conclusion: The optimized SVM model provides a reliable, data-driven approach for individualized ectasia-risk assessment in refractive surgery. By combining biomechanical and tomographic features, it enables early identification of high-risk patients and supports personalized surgical planning and postoperative monitoring. Further multi-center and long-term validation is warranted to enhance generalizability and clinical implementation.
Author: Tianyu Shi
Language: English
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,610
OpenAlex ID: W4415356385