Work

Discovery of Potent and Orally bioavailable Benzoazepinamine-Based SHP2 Allosteric Inhibitors for the Treatment of Inflammatory Diseases

Year: 2025

Type: article

Source: Journal of Medicinal Chemistry

DOI: 10.1021/acs.jmedchem.5c01578

Authors: Wenhua Jiang, Qiangqiang Hou, Dexiang Hua, Yi Zeng, Chenyang Huang, Guangmei Luo, Kangming Li, Zijie Jin, Xiaoyu Chen, Wenqiang Li, Wei Li, Qian Chu, Zhiyong Jiang, Xiaoxing Wu

Institutions: China Pharmaceutical University, Henan University, Henan Normal University

Language: English

Topic: Protein Tyrosine Phosphatases

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: closed

Funder: National Natural Science Foundation of China

Awards: G118709225, G1822563954, G6032029852, G6694429019

OpenAlex ID: W4415356460

FWCI:

Cites: 54

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