Work

Identification of IL18/IL18R1 signaling as a predictive biomarker of SGLT2 inhibitor efficacy in type 2 diabetes

Year: 2025

Type: article

Abstract: = 0.005; cutoffs: IL-18 = 244.29 pg/mL, IL-18R1 = 325.97 pg/mL). IL-18/IL-18R1 signaling emerges as a promising biomarker for predicting therapeutic responses, guiding clinical decisions regarding SGLT2i use in T2DM management.

Source: iScience

DOI: 10.1016/j.isci.2025.113594

Authors: I-Jou Teng, Chien-Hsing Lee, Ying-Chen Chen, Sheng-Chiang Su, Chieh-Hua Lu, Peng-Fei Li, Chia-Luen Huang, Li-Ju Ho, Ming-Hsun Lin, Hsin-Ya Liu, Feng-Chih Kuo

Institutions: Tri-Service General Hospital, National Defense Medical Center

Language: English

Topic: Diabetes Treatment and Management

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: National Science and Technology Council, National Defense Medical Center, Academia Sinica, Ministry of Science and Technology, Taiwan, Tri-Service General Hospital, Kaohsiung Veterans General Hospital

Awards: Using Blood-Based Dna Methylome to Examine Hyperglycemia-Mediated Metabolic Footprints and Their Dynamics under Sglt2i Treatment with Construction of Predictive Modeling for Therapeutic Response, G3264954672, G7158237676, Evaluate the Associations between Body Fat Distribution, Metabolic Diseases, Cancer and Chronic Renal Failure and Validate the Functional Roles of Hotair Downstream Target Genes in Human Regional Adipose Tissue, G7725909302

OpenAlex ID: W4415356697

FWCI: 1.212

Cites: 45

Cited by: 2

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