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Oral Undifferentiated Pleomorphic Sarcoma: A Case Report

Year: 2025

Type: article

Abstract: Undifferentiated pleomorphic sarcoma is a common soft tissue sarcoma in the human body, but it is rarely reported in the oral cavity. This article aims to report a case of UPS in the mandible. An 83-year-old female patient was referred to the Department of Oral and Maxillofacial Pathology at the Faculty of Dentistry in Isfahan, Iran, with a complaint of sudden, painless swelling under her removable complete denture, which had grown gradually over three months. The size of the lesion was approximately 5cm, and there were no radiographic defects present. Neoplastic and malignant proliferation of cells, which is necessary for UPS final diagnosis, was present in the H&E microcopy evaluation. Furthermore, immunohistochemical examination proved that the lesion is an undifferentiated pleomorphic sarcoma. Because of the late diagnosis of the disease, the patient died due to lung metastasis before any treatment.

Source: Journal of Craniomaxillofacial Research

DOI: 10.18502/jcr.v12i2.19972

Authors: Saeedeh Khalesi, Mohammad Parsa Ghazi, Bijan Movahedian Attar, Seyed Mohammad Razavi

Institution: Isfahan University of Medical Sciences

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415361987

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