Wearable Monitoring Captures Sleep Disturbances in Patients With Chronic Inflammatory Demyelinating Polyneuropathy
Year: 2025
Type: article
Study design: Observational Study
Abstract: BACKGROUND AND AIMS: Previous studies suggest that patients with chronic inflammatory demyelinating polyneuropathy (CIDP) experience impaired sleep, contributing to fatigue. Traditional methods like polysomnography or questionnaires are resource-intensive and may not capture sleep in natural settings. We explored whether widely available consumer-grade smartwatches offer a feasible way to assess sleep quality in this population. METHODS: The Electronic Monitoring of Disease Activity in patients with CIDP (EMDA-CIDP) study was a prospective observational study conducted from January 2023 to July 2024 at the University Hospitals of Düsseldorf and Münster. 46 patients had nighttime sleep recorded for 6 months via smartwatch. Additionally, clinical scores (e.g., Inflammatory Rasch-built Overall Disability Scale), sleep (PSQI, Pittsburgh Sleep Quality Index), and quality of life (QoL) questionnaires were collected every 3 months. RESULTS: Of 46 participants, 40 met adherence criteria (≥ 75% wear time on ≥ 75% of nights, median age: 66 years [IQR: 59.5-70.3], 9 [22.5%] female). Median PSQI score was 6 (4-7.6), sleep efficiency 93% (92-95), and WASO (wake after sleep onset) 32 min (24-42). Smartwatch-derived objective sleep measures - sleep efficiency and WASO - correlated significantly with PSQI (Spearman's R = -0.49, R = 0.40), clinical scores, and QoL. INTERPRETATION: Sleep is impaired in patients with CIDP and contributes to the overall disease burden. Our findings suggest that sleep disturbances can be tracked longitudinally using smartwatch-derived markers. Integrating digital health data presents promising opportunities for long-term sleep monitoring in this population. Larger studies, ideally incorporating polysomnography, are warranted to validate these findings.
DOI: 10.1111/jns.70069
Authors: Jan Voth, Charlotte von Gall, Noëmi Gmahl, Noah M. Werner, Gerd Meyer zu Hörste, Sven G. Meuth, Marc Pawlitzki, Lars Masanneck
Language: English
Topic: Sleep and related disorders
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: hybrid
Estimated APC paid: $4,550
Funders: Sanofi, Biogen, Teva Pharmaceutical Industries, Alexion Pharmaceuticals, Celgene, B. Braun-Stiftung, Amicus Therapeutics, Fresenius Medical Care North America, Argenx, Deutscher Akademischer Austauschdienst, Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Novo Nordisk, Deutschen Multiple Sklerose Gesellschaft, Ministerium für Kultur und Wissenschaft des Landes Nordrhein-Westfalen, Neuraxpharm, Gemeinsame Bundesausschuss, MedDay Pharmaceuticals, Chugai Pharmaceutical, Bundesinstitut für Risikobewertung
OpenAlex ID: W4415362193