Work

Hydromorphone ameliorates postoperative pain and depressive disorder in women receiving cesarean section under spinal anesthesia

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: Background: Pain and depressive mood disorders during cesarean sections negatively impact both mothers and infants. Studies have shown that hydromorphone has positive effects on both pain management and depressive mood disorders. This study examines how hydromorphone influences postoperative pain and depressive disorders in parturients undergoing cesarean sections under spinal anesthesia. Methods: This single-center, controlled, randomized trial involved 130 patients. Parturients in the intervention (H) group received patient-controlled intravenous analgesia (PCIA) with hydromorphone combined with sufentanil, while those in the control (S) group received sufentanil alone. All cesarean sections were performed under spinal anesthesia. Postoperative pain scores at rest and during movement were assessed using the Visual Analog Scale (VAS) at 4 h (T0), 8 h (T1), 12 h (T2), 24 h (T3), and 48 h (T4) postoperatively. The Beck Depression Inventory (BDI) and Beck Anxiety Inventory (BAI) were utilized to measure depressive and anxiety disorders at 3 days and 6 weeks postoperatively. Adverse reactions were also recorded. Results: = 0.619). Conclusion: The synergistic use of hydromorphone and sufentanil in PCIA provides superior analgesia for postoperative pain and decreases postoperative depression and anxiety scores in parturients undergoing cesarean sections.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1604600