Work

Evidence for food-related and non-food-related maladaptive preference in a mouse model of binge eating disorder

Year: 2025

Type: article

Abstract: Introduction: Rising numbers of binge eating disorder (BED) cases and excessive associated economic costs, together with the absence of efficient treatment strategies, highlight the importance of research in this area. To date, numerous studies have investigated the role of aberrant motivation in compulsive, maladaptive feeding behaviors. However, other aspects of maladaptive preference toward foods, possibly involving risk-based decision-making processes, are not yet fully elucidated. Methods: In this research, two types of environmental stressors-food-related and non-food-related-are explored in their ability to model compulsive behavior toward palatable food in mice. Results and discussion: Results from the behavioral experiments suggest that both types of stressors, when paired with the availability of highly palatable food, can produce aberrant motivation toward such food. These findings were subsequently supported by data obtained from cortisol concentration analysis in subjects.

Source: Frontiers in Behavioral Neuroscience

DOI: 10.3389/fnbeh.2025.1653807

Authors: Daniela Vajdová, Janet Ježková, Petra Procházková, Radka Roubalová, Enrico Patrono

Institutions: University of New York in Prague, Charles University, Czech Academy of Sciences, Institute of Microbiology

Language: English

Topic: Eating Disorders and Behaviors

Subfield: Clinical Psychology

Field: Psychology

Domain: Social Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801