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Drug-Induced Liver Injury Secondary to Turmeric Supplement Containing Piperine: A Case Report

Year: 2025

Type: article

Abstract: We present the case of a 35-year-old male with jaundice, fatigue, pruritus, and decreased appetite, ultimately diagnosed with drug-induced liver injury (DILI) secondary to a turmeric (curcumin) supplement containing piperine. DILI is defined as liver injury caused by a drug, herbal product, or dietary supplement that results in biochemical or clinical evidence of liver dysfunction after exclusion of other causes. A comprehensive evaluation of this patient ruled out viral, autoimmune, ischemic, obstructive, and metabolic etiologies. Liver tests normalized following discontinuation of the supplement, and the patient experienced full clinical recovery. This case emphasizes the need for clinicians to recognize the potential hepatotoxicity of turmeric-piperine supplements and to evaluate supplement use in cases of unexplained liver injury.

Source: Cureus

DOI: 10.7759/cureus.95076

Authors: Nayeong Koo, Harthik Kambhampati, Michael Herman

Institutions: Lake Erie College of Osteopathic Medicine, Borland Groover Clinic

Language: English

Topic: Drug-Induced Hepatotoxicity and Protection

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415377974