Work

Does vitamin B12 influence clinical pregnancy outcome in the follicular-phase GnRH agonist protocol?

Year: 2025

Type: article

Abstract: PURPOSE: To investigate whether vitamin B12 levels affect IVF-ET pregnancy outcomes. DESIGN: Single-center, retrospective, observational study. DESIGN: Single-center, retrospective, observational study. MAIN OUTCOME MEASURES: The primary outcome was the clinical pregnancy rate (CPR). RESULTS: After adjusting for Age, BMI, AMH, number of oocytes retrieved, cleavage-stage embryos/blastocysts, and the number of transferred embryos, when the vitamin B12 value was ≤358.7 pg/ml, for every 10 pg/ml increase in the vitamin B12 value, the clinical pregnancy rate increased by 4% (OR=1.04, 95% CI=1.00, 1.08, P=0.03). CONCLUSION: Within a specific range (≤358.7 pg/mL), serum vitamin B12 levels may modestly contribute to improved clinical pregnancy rates in women undergoing IVF-ET with the follicular-phase GnRH agonist protocol, though further validation is required to confirm its clinical significance. TRIAL REGISTRATION: None.

Source: BMC Pregnancy and Childbirth

DOI: 10.1186/s12884-025-08250-3

Authors: Xiaoning Wang, Kui Fu, Ying Zhang, Shengfang Jiang, Changjun Zhang

Institution: Hubei University of Medicine

Language: English

Topic: Folate and B Vitamins Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,290