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Epimedin C: A promising neuroprotective agent that can participate in mediating the JNK/Nrf2/HO‑1 signaling pathway to prevent neurodegenerative diseases

Year: 2025

Type: article

Abstract: group, after intervention with Epimedin C, p-JNK was significantly downregulated, Nrf2 and HO-1 were significantly upregulated, BAX was significantly downregulated and Bcl-2 was upregulated. In conclusion Epimedin C may improve OS in PC12 cells, exert neuroprotective effects and reduce apoptosis by inhibiting JNK phosphorylation and activating Nrf2/HO-1. Epimedin C may thus be considered a potential candidate neuroprotective agent for preventing neurodegenerative diseases.

Source: Experimental and Therapeutic Medicine

DOI: 10.3892/etm.2025.12998

Authors: Chao Cong, Xuan-Ling Li, Guang-Yao Lin, Lian-Wei Xu

Institutions: Shanghai University of Traditional Chinese Medicine, Longhua Hospital Shanghai University of Traditional Chinese Medicine

Language: English

Topic: Medicinal Plant Pharmacodynamics Research

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415380655

FWCI: 0.866

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Cited by: 1

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