Molecular phenotypes in early gallbladder and liver disease in the CFTR −/− sheep highlight aspects of cystic fibrosis-relevant hepatobiliary disease
Year: 2025
Type: article
Abstract: We use a physiological genomics approach to further understand the etiology of cystic fibrosis gallbladder and liver disease by using a large animal (sheep) model of organ development. We find that the gallbladder in the CFTR −/− animals is both structurally and functionally compromised by midgestation. We also observe functional immaturity in the CFTR −/− liver at term, where genes associated with many key metabolic processes do not show the upregulation seen at term in wild-type liver.
Source: Physiological Genomics
Institutions: Case Western Reserve University, Utah State University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Funder: Cystic Fibrosis Foundation
OpenAlex ID: W4415380679