Work

Esketamine versus sufentanil as analgesics for sedation during painless gastrointestinal endoscopy: a double-blinded randomized controlled trial

Year: 2025

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: BACKGROUND AND OBJECTIVE: Most troubling of painless gastrointestinal endoscopy is hypoxia and hypotension. Esketamine has sympathomimetic and respiratory protection, which combined with midazolam and propofol may reduce these troubles. So, this study aims to explore the efficacy and safety of this regimen. METHODS: < 93%) during the examination was observed. RESULTS: Compared with the Suf, the Esk group reduced the incidence of hypotension (12.8% vs 36.2%, 95% confidence interval (CI) 13.20-33.09, P < 0.001), respiratory depression (apnea > 30 s) (2.1% vs 15.4%, 6.47-20.52, P < 0.001), and hypoxia (7.1% vs 16.1%, 1.07-16.92, P = 0.018), but may increase the incidence of coughing (P < 0.001) and increased secretions (P = 0.032). There was no significant difference in the examination and recovery time (P > 0.05). CONCLUSION: Esketamine, midazolam, and propofol for painless gastrointestinal endoscopy can achieve opioid-free sedation and reduce the occurrence of hypotension and hypoxia. However, the dosages of this regimen need to be further explored to avoid coughing and increased secretions. TRIAL REGISTRATION: This study has been registered in the Chinese Clinical Trial Center ( https://www.chictr.org.cn/index.html , Date: November 3, 2022, No: ChiCTR2200065379).

Source: Trials

DOI: 10.1186/s13063-025-09073-5

Authors: Ting-Ting Li, Xiao-Lan He, Hai-Ling Tang, Qi-jun Li, Si-Ru Lian, Xiao Wang