Relationships between QRS duration and left ventricular deformation in hypertrophic cardiomyopathy
Year: 2025
Type: article
Study design: Observational Study
Abstract: Background: QRS duration has been recognized as a risk factor for ventricular arrhythmias in hypertrophic cardiomyopathy (HCM), but its role in reflecting left ventricular (LV) function and morphology is unknown. We aimed to investigate the relationship between QRS duration and strain values in hypertrophic nonobstructive cardiomyopathy (HNCM) and hypertrophic obstructive cardiomyopathy (HOCM). Methods: A total of 45 HNCM patients and 81 HOCM patients with preserved ejection fraction were retrospectively enrolled in this study. The QRS duration was measured using standard 12-lead electrocardiograms. LV global and segmental strain analyses were performed using cardiac magnetic resonance feature tracking. Results: , P=0.020) were decreased in HOCM patients. LV deformation and strain impairments occurred from the apex to the basal and mainly involved the apical segments in HNCM patients with prolonged QRS duration. In addition, the basal inferoseptal segmental circumferential strain and strain rate were reduced in HOCM patients with prolonged QRS duration. Conclusions: The QRS duration increases with global and segmental impairments in both HNCM and HOCM patients. Prolonged QRS duration may serve as an indicator of apical deformation in HNCM patients and as an indicator of mid-wall involvement in HOCM patients.
Authors: Shi Chen, Mingxuan Duan, Xi Zhao, Dakui Zhang, Hongyun Qin, Shuoyan An, Beiyao Gao, Xiaoyan Zhao
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415386508
FWCI:
Cites:
Cited by:
Related to: