Work

Asymmetric Synthesis of Isoindolines Featuring N ‐substituted Quaternary Carbon Centers through Stereoselective Intramolecular Aza‐Michael Reactions

Year: 2025

Type: article

Abstract: This paper describes the asymmetric construction of N-substituted quaternary carbon centers through the phase-transfer-catalyzed stereoselective intramolecular aza-Michael reaction of β,β-disubstituted, α,β-unsaturated esters, and nitriles with chiral sulfinamides used as nucleophiles. This reaction efficiently yielded chiral 1,1-disubstituted isoindolines with yields ranging from 41% to 90% and excellent diastereoselectivities (diastereomeric ratio between 7.8:1 and > 20:1).

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.202500819

Authors: Yu‐Ming Lin, Cheng‐Che Tsai

Institution: Tunghai University

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Shanghai Educational Development Foundation, National Science and Technology Council

Award: G7404734127