Work

Association of Neck Circumference With Cardiometabolic Risk Factors and Diseases in the German National Cohort

Year: 2025

Type: article

Abstract: Context: Neck circumference (NC) was proposed as promising marker to assess body fat distribution and cardiometabolic risk. Objective: We aimed to assess associations of NC with anthropometric traits, cardiometabolic risk markers, and self-reported cardiometabolic diseases. Methods: NC was measured in a subsample (5865 participants) of the German National Cohort (NAKO Gesundheitsstudie, NAKO), study region Kiel. Linear and logistic regression models were applied to assess associations of NC with anthropometric and cardiometabolic risk markers and self-reported cardiometabolic diseases, including diabetes, heart failure, gout, and a composite end point "clinical CVD" (cardiovascular disease; combining history of angina pectoris, stroke, myocardial infarction, and peripheral artery disease). Models were adjusted for sex and age, CV risk factors (systolic blood pressure, diabetes, low-density lipoprotein [LDL] cholesterol, use of lipid-lowering and antihypertensive medication, smoking status), and body mass index (BMI). Results: (β = .02 [0.01-0.02]), nonfasting glucose (β = .57 [0.31-0.83]), and inversely associated with high-density lipoprotein cholesterol (β = -.73 [-0.91; -0.54]). Furthermore, NC showed associations with diabetes (odds ratio [OR] = 1.08 [1.02-1.15]), heart failure (OR = 1.12 [1.02-1.23]), and gout (OR = 1.09 [1.01-1.17]). Association with "clinical CVD" did not remain statistically significant after BMI adjustment. Conclusion: NC was associated with several cardiometabolic risk factors, including glycemic and lipid traits and self-reported cardiometabolic diseases. These observations suggest that NC may be a useful surrogate marker for cardiometabolic risk.

Source: Journal of the Endocrine Society

DOI: 10.1210/jendso/bvaf163