Get started
Work

Appetite responses to different doses of cottonseed oil in adults at risk of cardiovascular disease

Year: 2025
Type: article
Abstract: High doses of cottonseed oil (CSO) have improved markers of appetite. The objective of this study was to examine dose response effects of CSO vs. a control (CON) diet on appetite responses in adults at risk for cardiovascular disease (CVD). This 28-day parallel outpatient feeding intervention randomized participants into a CSO dose group: LOW (10 % estimated energy needs (EEN) CSO; n = 23), MID (20 % EEN CSO; n = 23), or HIGH (30 % EEN CSO; n = 22) or CON (10 % EEN from oil mixture; n = 23). At pre- and post-intervention, participants consumed a high fat meal challenge with 5-hr postprandial blood draws to evaluate cholecystokinin, peptide YY (PYY), and ghrelin. Participants completed VAS questionnaires for subjective appetite at the same timepoints and hourly the remainder of the day with a food record. From pre- to post-intervention, postprandial ghrelin and PYY were suppressed in LOW and HIGH (p < 0.01 for all) vs. MID and CON (p > 0.05 for all). Subjective hunger was suppressed in LOW, MID, and HIGH (p < 0.01 for all) vs. CON (p = 0.93). Fullness in all CSO groups increased (p < 0.01 for all) vs. a reduction in CON (p = 0.04). Desire to eat was suppressed in LOW, MID, and CON (p < 0.01 for all) vs. HIGH (p = 0.95), and overall subjective appetite decreased in LOW and MID (p < 0.01 for both) vs. HIGH and CON (p > 0.05 for both). Altogether, enriching diets with 10 %, 20 %, and 30 % CSO improved markers of subjective appetite only in adults at-risk for CVD.
DOI: 10.1016/j.physbeh.2025.115138
Language: English
Open Access status: hybrid
Estimated APC paid: $3,500
OpenAlex ID: W4415390650
FWCI:
Cites: 41
Cited by:
Related to: