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Colchicine and Cardiovascular Disease: Mechanisms, Clinical Evidence, and Therapeutic Perspectives

Year: 2025

Type: article

Abstract: Colchicine, a long-established anti-inflammatory agent, has recently drawn growing interest due to its possible therapeutic roles in cardiovascular disorders. By modulating inflammatory pathways, colchicine has been shown to enhance clinical outcomes in patients with pericarditis, coronary artery involvement, as well as postoperative atrial fibrillation, and to lower the risk of recurrent cardiovascular events. Nevertheless, its underlying pharmacological mechanisms and sustained benefits still warrant comprehensive evaluation. This review summarizes current understanding of colchicine’s mechanisms, clinical evidence, and prospective applications, offering updated perspectives for its use in cardiovascular medicine.

Source: Cardiovascular Reviews

DOI: 10.26689/cr.v3i3.12333

Authors: Zhiyang Lv, Xiaodi Chen, Qing Lu, Shifang Ding

Institutions: China Three Gorges University, Yichang Central People's Hospital, General Hospital of Central Theater Command, Southern Medical University

Language: English

Topic: Gout, Hyperuricemia, Uric Acid

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W4415397807

FWCI:

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