Integration of Mesoporous Copper Coordination Polymer in Electrochemical Platform for Detection of Fluoroquinolone Antibiotic in Biological and Food Samples
Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide Antibiotics are indispensable in both human and veterinary medicine. However, their extensive and indiscriminate use has raised serious environmental and public health concerns, particularly regarding the emergence of antibiotic-resistant bacteria. In this context, continuous monitoring of broad-spectrum antibiotics, such as fluoroquinolone class, is essential. This study reports the development of an electrochemical sensor based on a copper-based coordination polymer, [Cu(C 8 H 4 O 4 )] n /CPE, for the detection of fluoroquinolone antibiotic (ciprofloxacin, CIP) in synthetic urine and egg samples. [Cu(C 8 H 4 O 4 )] n was synthesized via a solvothermal method, employing 1,4-benzenedicarboxylic acid as the organic ligand and copper salt as the metal source. The material was characterized by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), scanning electron microscopy with energy dispersive spectroscopy (SEM-EDS), thermogravimetric analysis (TGA), and Brunauer–Emmett–Teller (BET) surface area analysis. Electrode modification was optimized by varying the modifier content, pH solution, and electrochemical technique. Optimization using differential pulse voltammetry (DPV) revealed ideal conditions at pH 6.0 with 20% (w/w) [Cu(C 8 H 4 O 4 )] n . Under this condition, the sensor exhibited excellent linearity ( R 2 = 0.992), recoveries ranging from 78 to 108%, and relative standard deviation (RSD) bellow 10% ( n = 3). The limits of detection (LOD) and quantification (LOQ) were 0.5 and 1.7 μmol L –1 in synthetic urine and 3.0 and 10.1 μmol L –1 in egg sample, respectively. The [Cu(C 8 H 4 O 4 )] n /CPE sensor demonstrated high sensitivity and accuracy, highlighting its potential as reliable tool for monitoring CIP residues in food products and biological samples, thereby contributing to food safety and public health.
Source: ACS Omega
Institution: Universidade Federal de Viçosa
Language: English
Subfield: Electrical and Electronic Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $1,935
Awards: G1509849843, G22113365, DESENVOLVIMENTO DE UM MICRODISPOSITIVO COLORIMÉTRICO BASEADO EM REDE METALORGÂNICA (MOF), MEMBRANA DE CELULOSE E TECNOLOGIA SMARTPHONE PARA A DETECÇÃO DE BACTÉRIAS PATOGÊNICAS EM PRODUÇÃO DE QUEIJO MINAS ARTESANAL: UM FOCO NO FORTALECIMENTO DA AGROINDÚSTRIA FAMILIAR, G3224433735, G3690646728, ELABORAÇÃO DE UM MICRODISPOSITIVO ANALÍTICO BASEADO EM MEMBRANA DE CELULOSE E REDE METALORGÂNICA (MOFS) PARA DETECÇÃO COLORIMÉTRICA DE METAIS TÓXICOS EM ÁGUAS DA BACIA DO RIO DOCE (MARIANA/MG) USANDO SMARTPHONE COMO DETECTOR, PREPARAÇÃO DE UM NOVO NANOCARREADOR A BASE DE NANOPARTÍCULA MAGNÉTICA, QUITOSANA E CURCUMINA PARA O TRATAMENTO DA DOENÇA DE ALZHEIMER: SÍNTESE, CARACTERIZAÇÃO, ESTUDOS IN VITRO E IN VIVO, SÍNTESE DE NANOCATALISADORES A BASE DE NIÓBIO PARA PRODUÇÃO DE HIDROGÊNIO COMBUSTÍVEL
OpenAlex ID: W4415405726