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Case Report: successful treatment of severe bronchiectasis by inhalation of mesenchymal stem cell-derived exosomes

Year: 2025

Type: article

Abstract: Bronchiectasis is a chronic respiratory disorder characterized by irreversible airway dilation and recurrent infections, remains a therapeutic challenge. MSCs-exosomes based treatment is a potential treatment for respiratory disease; however, data regarding the efficacy of this novel therapy are currently lacking. We present a case of bronchiectasis treated with inhaled exosomes derived from human umbilical cord mesenchymal stem cells. As demonstrated in this patient, MSCs-exosomes inhalation may provide comprehensive benefits including reversal of hypoxemia, which could potentially result in enhancement of clinical outcomes and quality of life, and reduction in mortality.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1690559

Authors: Yanyi Liu, Kun Xia, Haoxiang Zhang, Guangxi Li

Institutions: China Academy of Chinese Medical Sciences, Guang’anmen Hospital

Language: English

Topic: Cystic Fibrosis Research Advances

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801