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Research Communication: Changing Aetiology of Chronic Liver Diseases in East Asia Pacific and HCC Surveillance in Non‐Cirrhotic Patients

Year: 2025

Type: article

Abstract: East Asia Pacific (EAP) faces a high burden of chronic liver disease (CLD), with metabolic dysfunction-associated steatotic liver disease (MASLD) projected to account for about 80% of CLD prevalence by 2040. Using Global Burden of Disease 2021 data, we assessed CLD trends, transitions to hepatocellular carcinoma (HCC), and the cost-effectiveness of non-cirrhotic HCC surveillance. Despite declining viral hepatitis burden, MASLD and alcohol-related CLD have risen. HCC surveillance in non-cirrhotic patients was cost-effective only for chronic hepatitis B in selected older age groups, with substantial variability across countries. These findings support refining surveillance guidelines and adaptation of risk stratification tools.

Source: Alimentary Pharmacology & Therapeutics

DOI: 10.1111/apt.70428

Authors: Ming Liu, Chuan Liu, Tsz Ngai Mok, Xiaolong Qi, Wai‐kit Ming

Institutions: City University of Hong Kong, Zhongda Hospital Southeast University, State Key Laboratory of Digital Medical Engineering, Southeast University

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $5,250