Work

Clinical features and outcomes of pregnancies complicated by coexisting gestational diabetes and hypertensive disorders

Year: 2025

Type: article

Abstract: Background Gestational diabetes mellitus (GDM) and hypertensive disorder complicating pregnancy (HDP) share pathophysiological mechanisms that increase the risk for adverse maternal and neonatal outcomes. However, their combined impact remains underexplored. Objective To assess the clinical characteristics, therapeutic interventions, and maternal–fetal outcomes in pregnancies complicated by both GDM and HDP. Methods A retrospective study was conducted involving 82 women with GDM complicated by HDP and 118 healthy pregnant controls. Clinical parameters, mode of delivery, and pregnancy outcomes were compared between groups. Logistic regression analysis was performed to identify independent predictors of GDM complicated by HDP. Results Women with GDM complicated by HDP exhibited significantly higher pre-pregnancy weight, body mass index (BMI), fasting blood glucose, triglycerides, and high-density lipoprotein (HDL) cholesterol compared with healthy controls ( p < 0.05). Logistic regression identified these variables as independent predictors of GDM + HDP ( p < 0.001). The GDM + HDP group also had higher rates of cesarean delivery and adverse pregnancy outcomes. Individualized treatment targeting glycemic and blood pressure control significantly improved metabolic parameters and reduced the incidence of complications ( p < 0.05). Conclusion Pre-pregnancy metabolic factors, including BMI, fasting blood glucose, triglycerides, and HDL cholesterol, are strong predictors of GDM complicated by HDP. Early identification and individualized management of these high-risk pregnancies can effectively reduce adverse maternal and neonatal outcomes.

Source: Frontiers in Medicine

DOI: 10.3389/fmed.2025.1656391

Authors: Chaoying Jia, Lanying Bo, Shu Xiao, Shunlan Du

Institution: Wenzhou Medical University

Language: English

Topic: Gestational Diabetes Research and Management

Subfield: Obstetrics and Gynecology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801