Scope and Synthetic Applications of the Aryl-Alcohol Oxidase from Streptomyces hiroshimensis ( Sh AAO)
Year: 2025
Type: article
Abstract: High Resolution Image Download MS PowerPoint Slide The sustainable production of carbonyl compounds is of growing interest due to their broad academic and industrial interest. Herein, we explored the aryl-alcohol oxidase from Streptomyces hiroshimensis ( Sh AAO), mapping its activity across diverse alcohols, revealing a distinct profile from other natural AAOs. Integrated into tandem organocatalytic processes, Sh AAO enabled the synthesis of various chiral compounds, including an intermediate for paroxetine. Gram-scale reactions delivered high yields and turnover numbers exceeding 65000. Immobilization further enhanced stability, highlighting Sh AAO as an efficient and industrially relevant biocatalyst.
Source: Organic Letters
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $4,500
Funders: Ministerio de Ciencia, Innovación y Universidades, Keele University, Universidad de Oviedo, Universidad de Zaragoza, Gobierno de Aragón, Consejo Superior de Investigaciones Científicas, European Regional Development Fund, Agencia Estatal de Investigación, European Social Fund, NextGenerationEU
Awards: G1561925909, G1828573866, Química de oro y plata, G2262748287, G300979063, G3020948319, G3480869486, G3695550728, G3845300180, G425668148, G464105488, G4695131866, G4744015703, G4893745188, G5080475149, G5148264914, G5338730000, G5958938698, G6080697404, G6218905885, G7084143925, G7421108529, G8233766029, G8512376126, G855041801, G8574095611, G8709270594, G8867809279
OpenAlex ID: W4415420524