Polyacrylamide–Sodium Alginate Hydrogel Scaffolds With Calcium Aminopolycarboxylate Coordination Polymers for Enhanced Calcium Mineralisation in Osteoblast‐Like Cells
Year: 2025
Type: article
Abstract: In this study, calcium aminopolycarboxylate-based coordination polymers, calcium acetamidoiminodiacetate (CaADA) and tetraaqua(ethylenediaminetetraacetato)-calcium (II) strontium (II) monohydrate (SrCaEDTA) were incorporated into polyacrylamide-sodium alginate hydrogel scaffolds, aiming to improve calcium absorption in MG-63 cells. Cytotoxicity of the coordination polymers in MG-63 osteoblast-like cells was studied by MTT assay. The mechanical performance and degradation behaviour of the scaffolds were systematically investigated. Porosity measurements were done via SEM analysis, and calcium ion release profile was evaluated by inductively coupled plasma mass spectrometry (ICP-MS) measurements. The calcium deposition studies revealed that the integration of the coordination polymers enhanced the calcium absorption in MG-63 cells. The coordination polymer-incorporated hydrogel scaffolds can be developed as future materials for bone tissue engineering and bone repair applications.
Source: Biopolymers
DOI: 10.1002/bip.70057
Authors: Sabitha Mohan M. R., Rani Pavithran
Institutions: University of Kerala, College of Engineering Trivandrum
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W4415432108