Work

Effectiveness and Safety of Mirabek Sustained-release 50 mg Tablets in Korean Patients with Overactive Bladder: A Multicenter Observational Study at Tertiary General Hospitals

Year: 2025

Type: article

Abstract: Background and objective: -adrenergic agonist, is a key therapy for overactive bladder (OAB). This study aimed to evaluate the real-world effectiveness and safety of generic mirabegron (Mirabek) in Korean patients with OAB through a multicenter, prospective, noninterventional observational study at tertiary general hospitals. Methods: Adult patients with OAB newly prescribed Mirabek sustained-release 50 mg tablets were enrolled from 46 tertiary general hospitals. Assessments were performed at baseline and follow-up visits at 3 and 6 mo. Data collected included the OAB Symptom Score (OABSS), bladder diaries, uroflowmetry results, and adverse events. Key findings and limitations: < 0.0001), with the mean score improving from 6.9 to 4.6. All seven bladder diary parameters, including urgency and incontinence, showed significant improvement. Treatment satisfaction increased, and 67.3% of participants continued Mirabek at 6 mo. Adverse events occurred in 5.5% of participants, with 1.8% being drug related; all were mild. Conclusions and clinical implications: Mirabek (generic mirabegron) demonstrated effective symptom relief and was well tolerated in Korean patients with OAB, with sustained efficacy up to 6 mo. The introduction of Mirabek substantially reduced treatment costs and expanded access to mirabegron therapy. Patient summary: In this study, we looked at the effect of Mirabek, a generic medication for overactive bladder (OAB), in >4000 Korean patients treated in large hospitals. We found that Mirabek improved bladder symptoms such as urgency and frequent urination over 6 mo, with very few side effects. Most patients stayed on the treatment and reported feeling better, suggesting that this affordable medication can help more people manage their OAB effectively.

Source: European Urology Open Science

DOI: 10.1016/j.euros.2025.10.004

Authors: Jee Soo Park, Jongchan Kim, Moon-Hwa Park, Won Sik Jang

Institutions: Yonsei University, Yonsei University Health System, Yongin Severance Hospital, Hanmi Pharmaceutical (South Korea)

Language: English

Topic: Urinary Bladder and Prostate Research

Subfield: Urology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,800