Thermal behavior, crystal structure, spectroscopic and biological studies of novel Co(II), Ni(II) and Cu(II) complexes with indomethacin
Year: 2025
Type: article
Abstract: Three metal complexes with indomethacin (Hind), a popular nonsteroidal anti-inflammatory drug with the formulae: Co(ind) 2 (H 2 O) 4 ·H 2 O ( 1 ), Ni(ind) 2 (H 2 O) 4 ·H 2 O ( 2 ) and Cu 2 (ind) 4 ·(EtOH) 2 ( 3 ), were synthesized and characterized by elemental analysis and FTIR spectroscopy. The crystal structure of 2 and 3 was determined by the single-crystal X-ray diffraction analysis. The central atoms are coordinated by deprotonated indomethacin through carboxylate groups in two various modes. In 3, the typical dinuclear Cu–Cu paddle-wheel structural motif is observed. The powder X-ray diffraction data indicate that 1 and 2 are isostructural . For all complexes, TG/DTG/DTA analysis augmented by MS system was performed. Furthermore, the antioxidant properties of 1 – 3 complexes compared with free ligand were revealed. Additionally, antimicrobial and antifungal activity was tested.
Institutions: Lodz University of Technology, Medical University of Lublin
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Estimated APC paid: $3,790
Award: G6500905221
OpenAlex ID: W4415439445