Work

Speech Outcomes in 5-Year-Olds Born With Cleft Palate With and Without Robin Sequence—A Swedish Registry Study

Year: 2025

Type: article

Abstract: ObjectiveTo compare speech outcomes in 4 groups of 5-year-olds with cleft of the hard and soft palate: with Robin sequence without additional conditions (RS-), with Robin sequence with additional conditions (RS+), without Robin sequence with additional conditions (CP+), and without Robin sequence without additional conditions (CP-).DesignRegistry-based cohort study.SettingRegional public care university hospitals in Sweden.ParticipantsA total of 433 children with cleft of the hard and soft palate: 72 with RS-, 28 with RS+, 61 with CP+, and 272 with CP-.InterventionsPrimary cleft palate repair in 1 or 2 stages.Main outcome measuresDichotomized outcomes of percentage of consonants correct, percentage of nonoral speech errors, and velopharyngeal competence. Logistic regression was used for statistical analysis.ResultsChildren with RS+ had significantly lower odds of age-appropriate consonant production (OR 0.17, 95% CI 0.08-0.40), no nonoral speech errors (OR 0.17, 95% CI 0.07-0.39), and velopharyngeal competence (OR 0.24, 95% CI 0.10-0.56) than those with CP-. Significantly lower odds of age-appropriate consonant production were found for children with RS- (OR 0.50, 95% CI 0.29-0.88) and CP+ (OR 0.45, 95% CI 0.24-0.84) than children with CP-.ConclusionsBoth Robin sequence and additional conditions were associated with decreased odds of age-appropriate consonant production at 5 years of age. For children with RS+, the odds were further reduced, and they also had decreased odds of no nonoral speech errors and of velopharyngeal competence. The results can form the basis for informing parents and planning intervention.

Source: The Cleft Palate-Craniofacial Journal

DOI: 10.1177/10556656251387538

Authors: Kristina Klintö, Malin Schaar Johansson, Karin Brunnegård, Magnus Becker

Institutions: Lund University, Skåne University Hospital, Umeå University

Language: English

Topic: Cleft Lip and Palate Research

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,150