Work

Three Previously Undescribed Compounds Isolated From the Leaves of Syzygium antisepticum With Their α‐Glucosidase and Nitric Oxide Inhibitory Activity

Year: 2025

Type: article

Abstract: ABSTRACT Three previously undescribed compounds, 2α,3β,20α,23‐tetrahydroxy‐nor‐30‐urs‐12‐en‐28‐oic acid 28‐ O ‐β‐ d ‐glucopyranoside ( 1 ), 2α,3β,6β,23‐tetrahydroxyoleana‐11,13(18)‐dien‐28‐oic acid ( 2 ), and 4,6‐dihydroxy‐3‐methyl‐2‐ O ‐β‐ d ‐glucopyranosylbenzophenone ( 3 ), together with 11 known compounds ( 4 – 14 ) are isolated from the leaves of Syzygium antisepticum . The isolated compounds are characterized via HR–ESI–MS and NMR spectra. Compounds 1 , 2 , 6 , and 7 exhibited significant inhibition of NO production in lipopolysaccharide (LPS)‐activated murine macrophage RAW264.7 cells with IC 50 values of 16.3, 14.9, 25.5, and 24.7 µM, respectively. In addition, compounds 9 – 12 displayed the most potential α‐glucosidase with IC 50 values ranging from 23.6 to 162.0 µM.

Source: Chemistry & Biodiversity

DOI: 10.1002/cbdv.202501820