Year: 2025
Type: article
Abstract: DNA origami nanorobots allow for the rational design of nanomachines that respond to environmental stimuli with preprogrammed tasks. To date, this mostly is achieved by constructing two-state switches that, upon activation, change their conformation, resulting in the performance of an operation. Their applicability is often limited to a single, specific stimulus-output combination because of their intrinsic properties as two-state systems only. This makes expanding them further challenging. Here, we addressed this limitation by introducing reconfigurable DNA origami arrays as networks of coupled two-state systems. This universal design strategy enables the integration of various operational units into any two-state system within the nanorobot, allowing it to process multiple stimuli, compute responses using multilevel Boolean logic, and execute a range of operations with controlled order, timing, and spatial position. We anticipate that this strategy will be instrumental in further developing DNA origami nanorobots for applications in various technological fields.
Source: Science Robotics
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Awards: FMRG: Bio: Manufacturing Ultra-High-Density DNA-Enabled Nanoelectronics Systems, G2937822799, CONFORMATIONALLY-STEERED HIERARCHICAL SELF-ASSEMBLY AT SOLID SURFACES, G3429142973, SemiSynBio-III: Precision assembly and electronic properties of protein nanowire circuits using DNA origami, G4106036485, CNATM: Chemisch modifizierte Nukleoside, Nukleotide und Oligonukleotide als Therapeutika und Vakzine (Verbundprojekt 1) - A, DNA nanodevices for molecular interrogation and regulation of lymphocytes in adaptive immune system
OpenAlex ID: W4415440565