Effectiveness of Sasim-tang-gagam for Treating Cancer Treatment-induced stomatitis: A Systemic Review and Meta-analysis
Year: 2025
Type: article
Study designs: Systematic Review, Meta-Analysis
Abstract: Objectives: This study evaluated the efficacy of Sasim-tang-gagam (modified Xie-xin decoction) in managing cancer treatment-induced stomatitis through a systematic review and meta-analysis.Methods: Randomized controlled trials (RCTs) assessing Sasim-tang-gagam for stomatitis caused by cancer treatment were identified from 12 databases up to December 22, 2024. No restrictions were applied regarding cancer type, cancer treatment type, comparators, or outcome measures.Results: Eleven RCTs met the inclusion criteria. Six RCTs reported a 22% reduction in stomatitis incidence (RR=0.78, 95% CI: 0.62-0.98, p=0.03), with greater reductions observed when Sasim-tang-gagam was administered for ≥2 weeks. Three RCTs demonstrated a 24% higher treatment efficacy (RR=1.24, 95% CI: 1.13-1.37, p<0.0001). Symptom scores also decreased significantly (SMD=-2.08, 95% CI: -2.90 to -1.26, p<0.00001).Conclusion: Sasim-tang-gagam shows potential effectiveness and safety for managing cancer treatment-induced stomatitis. However, confirmation through large-scale, high-quality RCTs is needed.
Authors: Jeong-eun Lee, Yu-jin Choi, Seon-mi Shin
Institutions: Semyung University, Daejeon University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415454962