Periprosthetic joint infection of the knee complicated by primary localized cutaneous amyloidosis: a case report
Year: 2025
Type: article
Study design: Case Report
Abstract: Background: Primary localized cutaneous amyloidosis (PLCA) is characterized by amyloid protein deposition in the skin, leading to pigmentation, papules, and itching. The etiology of PLCA remains unclear. Periprosthetic joint infection (PJI) post-total knee arthroplasty (TKA) poses challenges in management. Case presentation: A PLCA patient underwent TKA and developed acute PJI, necessitating multiple surgical interventions. Recurrence of infection symptoms prompted a two-stage revision surgery approach. Conclusion: Skin lesions in PLCA patients may potentially contribute to the risk PJI following arthroplasty. Strategies such as using tacrolimus for itching management, along with prophylactic antibiotics during PLCA flare-ups, could potentially aid in preventing and managing PJI in this patient population. Further research is needed to elucidate the relationship between PLCA and PJI post-arthroplasty.
Source: Frontiers in Medicine
Authors: Xinxuan Lai, Qianjin Zhang, Fuxin Liu, Zhiqing Xu, Jinhua Guo, Hanglin Qiu, Fudong Xu, Zhikun Zhuang, Changyu Huang
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W4415457684