Long-term survival after multimodality treatment of metastatic mixed adenoneuroendocrine carcinoma of colon: A case report
Year: 2025
Type: article
Study design: Case Report
Abstract: BACKGROUND: Mixed adenoneuroendocrine carcinoma (MANEC) is a rare malignancy that can be effectively treated with surgery in its early stages. However, there is currently no established treatment protocol for metastatic cases. CASE SUMMARY: We present a case of a patient diagnosed with liver metastasis (LM) from ascending colon MANEC. The patient is a 40-year-old male who was diagnosed to have ascending colon MANEC with LM in March 2014. Following surgical resection of both the primary tumor and the LM, the patient received first-line chemotherapy with the mFOLFOX6 regimen. After six months of the initial treatment, the patient experienced multiple recurrences of LM. These LM were successfully treated by a multidisciplinary approach including chemotherapy, surgical resection, and radiofrequency ablation (RFA). Remarkably, in June 2017, the patient achieved a complete response, which has been maintained to date, resulting in overall long-term survival of ten years. Advanced colorectal MANEC is often associated with LM, and multiple intrahepatic recurrences may be characteristic of this disease. CONCLUSION: The use of local treatment modalities, such as surgery and RFA, in conjunction with chemotherapy, has demonstrated promising efficacy and warrants further investigation.
Authors: Jun Pan, Rong-Sheng Zhang, Ying Chen, Xiao-Hui Cao, Zhi-Hui Yang, Lu Lu, Yi-Tian Chen, Xiao-Yuan Chu
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4415465236