Work

Successful Re-administration of Granulocyte Colony-Stimulating Factor Without Recurrence of Associated Vasculitis: A Case Report

Year: 2025

Type: article

Abstract: We report a case of diffuse large B-cell lymphoma complicated by granulocyte colony-stimulating factor (G-CSF)-associated vasculitis following filgrastim administration. The vasculitis resolved with corticosteroid therapy, and maintenance treatment was continued long-term. During salvage chemotherapy for lymphoma relapse 14 months after the initial episode, G-CSF was reintroduced because of persistent myelosuppression. Filgrastim and pegfilgrastim were used in subsequent cycles without recurrence of vasculitis. This case suggests that G-CSF re-administration may be cautiously considered on an individual basis, particularly when vasculitis is well controlled with corticosteroids and a sufficient interval has elapsed. These findings may help guide individualized management in similar clinical situations.

Source: Cureus

DOI: 10.7759/cureus.95211

Authors: Kazuaki Teshima, Satoshi Takahashi, Shodai Takahashi, Nanako Fujita, Masaaki Kume, Naoto Takahashi

Institutions: Hiraka General Hospital, Akita University

Language: English

Topic: Neutropenia and Cancer Infections

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4415467399