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Targeted Endogenous Bioelectric Modulation in Autism Spectrum Disorder: Real-World Clinical Outcomes of the REAC BWO Neurodevelopment–Autism Protocol

Year: 2025

Type: article

Abstract: Autism Spectrum Disorder (ASD) involves atypical brain oscillatory dynamics and al-tered connectivity, impairing sensory integration, socio-communicative responsiveness, and behavioral regulation. Radio Electric Asymmetric Conveyer (REAC) technology delivers non-invasive neurobiological modulation through standardized, opera-tor-independent protocols. The Brain Wave Optimization Neurodevelopment–Autism (BWO ND-A) protocol was designed to modulate oscillatory patterns frequently altered in ASD, aiming to restore network coherence and improve multidomain functioning. This retrospective pre–post single-arm study evaluated 39 children with ASD (31 males, 8 females; mean age 7.85 ± 2.90 years). All received one Neuro Postural Optimization (NPO) session to prime central nervous system adaptive capacity, followed by BWO ND-A (18 sessions, ~8 minutes each), administered 3–4 times daily over ~two weeks. The primary outcome was change in Autism Treatment Evaluation Checklist (ATEC) total score; secondary outcomes were changes in its four subscales. Mean total ATEC decreased from 67.76 ± 16.11 to 56.25 ± 23.66 (mean change −11.51 ± 14.48; p < 0.0001; Cohen’s dz = 0.78). Clinically meaningful improvement (≥8-point reduction) occurred in 59% of participants. Significant reductions were observed across all subscales, with the largest effect in Sensory/Cognitive Awareness (dz = 0.68). No adverse events were reported. These findings indicate that NPO followed by BWO ND-A can rapidly improve multiple functional domains in pediatric ASD within a short treatment cycle. The protocol’s safety, reproducibility, and tolerability support its integration as an adjunct to existing interventions in clinical and community settings.

Source: Journal of Clinical Medicine

DOI: 10.3390/jcm14217500

Authors: Arianna Rinaldi, Hingrid Angélica Benetti Mota, Salvatore Rinaldi, Vania Fontani

Institution: University of Florence

Language: English

Topic: Autism Spectrum Disorder Research

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,137