The cognitive connectome in dementia with lewy bodies undergoes early alterations already at the mild cognitive impairment stage
Year: 2025
Type: article
Study design: Observational Study
Abstract: Cognitive impairment is required to diagnose mild cognitive impairment with Lewy bodies (MCI-LB). However, associations of impairments across cognitive domains remain unclear. In this cross-sectional study, we investigated these associations by assessing the cognitive connectome of MCI-LB patients compared with healthy controls (HC), mild cognitive impairment due to Alzheimer's disease (MCI-AD), and dementia with Lewy bodies (DLB). Using the National Alzheimer's Coordinating Center database, we built cognitive connectomes for MCI-LB (n = 88), HC (n = 3703), MCI-AD (n = 1789), and DLB (n = 104) by correlating 24 cognitive measures. We compared global and nodal network measures of centrality (importance of cognitive measure), integration (communication across cognitive measures), and segregation (specialisation of cognitive measures) between groups. For global measures, MCI-LB showed lower segregation than HC, with no significant differences from MCI-AD, and lower integration) and higher segregation than DLB. For nodal measures, MCI-LB compared with HC and MCI-AD showed differences in executive and memory measures, respectively. MCI-LB showed several nodal differences compared with DLB, involving executive, processing speed/attention, and language measures. Our findings suggest that MCI-LB involves early changes in the cognitive connectome, particularly reduced segregation that becomes more pronounced at the DLB stage and shows overlap with MCI-AD, offering insights into cognitive impairment in MCI-LB.
Source: Scientific Reports
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: G1020749929, G1024368718, G1048051091, G1058046096, G1069732457, G1075639496, G11426272, G117713310, G120189231, G1269895679, G1293354362, G1364373663, G1369195717, G1458362881, G1531775036, G1593128567, G1753564228, G1793654115, G1827328465, G1859882300, G2142974134, G2190936067, G2234397790, G2434699210, G253265979, G2622865600, G2632195949, G2675915175, G2742075923, G2887984396, G3284295768, G333817976, G3430734602, G343469054, G348743638, G3703765782, G371566797, G3818147302, G3952091757, G415047313, G4186766937, Nevada Exploratory Alzheimer's Disease Research Center (NVEADRC), G4390231255, UAB Alzheimer's Disease Research Center, G504619356, G5056789898, G5640525220, G6250057130, New Mexico Alzheimer's Disease Research Center, G726963014, G7380798711, G76412088, G816726602, G855012155, G8824643644, G9000000175, G9000000449, G9000004438, G9000011165, G9000011571, G9000015010, G9000015941, G9000038514, G9000041566, G9000044512, G9000056371, G9000059605, G9000060917, G9000063279, G9000065392, G9000065952, G9000079798, G9000081013, G9000082286, G9000085578, G9000087139, G9000087364, G9000091371, G9000100769, G9000112075, G9000114108, G9000115163, G9000134521, G9000148901, G9000182597, G9000183948, G9000208313, G9000224607, G9000226412, G9000254440, G9000266300, G9000271511, G9000290608, G9000305967, G9000315395, G9000320238, G9000330862, G9000331231, G9000332211, G9000341970, UCSD Shiley-Marcos Alzheimer's Disease Research Center P30, Joint Estimate Diffusion Imaging (JEDI) for improved Tissue Characterization and Neural Connectivity in Aging and Alzheimer's Disease, University of Kansas Alzheimer's Disease Research Center (KU ADRC), Alzheimer's Disease Research Center, Johns Hopkins Alzheimer's Disease Research Center, Stanford Alzheimer's Disease Research Center, University of Washington Alzheimer's Disease Research Center, Goizueta Alzheimer's Disease Research Center
OpenAlex ID: W4415477196